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Japenese researchers claim perfection in mice Re-Cloning to the 25th Generation

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recloning of mice

recloning of mice

Japanese researchers have succeeded in cloning mice that live just as long as regular mice, and they’ve been flawlessly cloned and recloned from the same source to the 25th generation.

Using the technique that created Dolly the sheep, researchers from the RIKEN Center for Developmental Biology in Kobe, Japan have identified a way to produce healthy mouse clones that live a normal lifespan and can be sequentially cloned indefinitely.

Their study is published today in the journal Cell Stem Cell.

In an experiment that started in 2005, the team led by Dr. Teruhiko Wakayama has used a technique called somatic cell nuclear transfer (SNCT) to produce 581 clones of one original ‘donor’ mouse, through 25 consecutive rounds of cloning.

SNCT is a widely used cloning technique whereby a cell nucleus containing the genetic information of the individual to be cloned is inserted into a living egg that has had its own nucleus removed. It has been used successfully in laboratory animals as well as farm animals.

However, until now, scientists hadn’t been able to overcome the limitations of SNCT that resulted in low success rates and restricted the number of times mammals could be recloned. Attempts at recloning cats, pigs and mice more than two to six times had failed.

“One possible explanation for this limit on the number of recloning attempts is an accumulation of genetic or epigenetic abnormalities over successive generations” explains Dr. Wakayama.

To prevent possible epigenetic changes, or modifications to DNA function that do not involve a change in the DNA itself, Wakayama and his team added trichostatin, a histone deacetylase inhibitor, to the cell culture medium. Using this technique, they increased cloning efficiency by up to 6-fold.

recloning of mice
Dr. Teruhiko Wakayama from the RIKEN Center for Developmental Biology, in his lab.

By improving each step of the SCNT procedure, they were able to clone the mice repeatedly 25 times without seeing a reduction in the success rate. The 581 healthy mice obtained in this way were all fertile, they gave birth to healthy pups and lived a normal lifespan of about two years, similar to normally conceived mice.

“Our results show that there were no accumulations of epigenetic or genetic abnormalities in the mice, even after repeated cloning,” conclude the authors.

Dr. Wakayama adds, “This technique could be very useful for the large-scale production of superior-quality animals, for farming or conservation purposes.”

Dr. Wakayama’s work made the news in 2008 when his team created clones from the bodies of mice that had been frozen for 16 years, using SNCT

Source: Press Release RIKEN Center for Developmental Biology

Madan has studied English Literature and Journalism from HP University and lives in Shimla. He is an amateur photographer and has been writing on topics ranging from environmental, socio-economic, development programs, education, eco-tourism, eco-friendly lifestyle and to green technologies for over 9 years now. He has an inclination for all things green, wonderful and loves to live in solitude. When not writing, he can be seen wandering, trying to capture the world around him in his DSLR lens.

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Himachal Records Fresh Spell of Snow, HP Met Issues Alert

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Shimla-The weather in Himachal Pradesh has taken a turn with a prediction of rain and snowfall till December 5, 2021. At the time of writing this report, Kaza in Lahaul-Spiti was receiving a fresh spell of snow, cheering the tourists, as well as, the hoteliers. So far, the traffic movement was normal in the region.

This has caused a sharp drop in temperatures across the state.

The District Administration of Lahaul-Spiti has advised the locals and tourists to avoid wandering to high altitude areas unnecessarily.

The HP Meteorological Department, Shimla, has also issued a yellow alert for December 2 and December 5. While the plains can experience light to moderate rainfall at a few places,  the middle and higher hills could witness widespread rain and snow on December 2.   

For December 4, the HP Met had predicted light to moderate rain across the state. For December 5, however, the Met has issued an yellow alert with a prediction of rain and snow at several places.

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UHF Nauni Extends Online Plant Booking Date Till Dec 7

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Plant booking at uhf nauni 2021

Solan-Dr. YS Parmar University of Horticulture and Forestry (UHF), Nauni has extended the last date for online booking of planting material prepared by the university’s main campus and its Krishi Vigyan Kendra(KVK) at Solan. Interested farmers will now be able to book plants on the university online portal till December 7.

This year the booking for the planting material of apple, plum, apricot, peach, kiwi, pear, pomegranate, persimmon, etc. is being done online and farmers can submit their demand for plants by logging on the university website and visiting the ‘Farmers corner’ section. The university has advised the farmers to register themselves through their email address on the university portal.

The farmers who have not been able to submit their demand forms have also been advised to resubmit their demand forms.  

Applicants will have to fill in their complete postal address and the Khasra number of the land where the planting is to be carried out along with their contact details. After the OTP-based registration process is complete, applicants will be able to book plants for varieties supplied by the university. The plant varieties available for sale and distribution on this web portal have been grafted on seedling rootstock. The procedure for the sale and distribution of Nursery Fruit Plants from other University Research Stations and KVK’s will be the same as in previous years.

The university will start the allotment process after the booking is closed. Based on the total demand, the university will allot plants out of the available quantity. The allotment list will be made available on the university portal. The farmers will be also be notified about the date on which the plant will be available and from which nursery they will be provided.

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HP Police Becomes 8th State Police of India to Receive Presidents Colour Award

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HP Police Presidents Colours award

Shimla-Himachal Pradesh Police organized the Presidents Colour Award ceremony at the historic Ridge Ground on December 1, 2021.

Governor Rajendra Vishwanath Arlekar was the Chief Guest and Chief Minister Jai Ram Thakur was also present as a special guest on the occasion. The Governor honoured the State Police with the Presidents Colour Award which was received by the Director-General of Police Sanjay Kundu.

While extending greetings and expressing happiness on receiving the Presidents Colour by Himachal Pradesh Police, the Governor said that it was the 8th State Police of India which has received this distinction.

“President Colour’ is a special achievement and this proves the state police ranks high in the service of humanity along with performance, professionalism, integrity, protection of human rights and other parameters,” said the Governor.

HP Police Presidents Colours award ceremony

The Governor honoured the State Police with the Presidents Colour Award which was received by the Director-General of Police Sanjay Kundu.

He added that this feat has also been given to the State Police for the contribution of its personnel, who have worked tirelessly over the years to make it reliable, professional, honest and people-friendly. He said it would definitely motivate the Police personnel and they would work more readily in public service.

While interacting with media on the occasion, Chief Minister Jai Ram Thakur congratulated the State Police for being awarded President’s Colours by the President of India for its meritorious services. He said that this Award was the highest point in the professional life of any uniform. 

Director-General of Police Sanjay Kundu said that the President’s Color’was not only an award but also a responsibility, which the Himachal Pradesh Police has to fulfil with more integrity, efficiency and discipline.

He added that every Jawan of the State Police should take a pledge to maintain security and peace in Devbhumi Himachal Pradesh.

Earlier, the Governor inspected the Parade. On the occasion, the formation of Hollow Square by the Police Band, Pilling of drums and consecration of the colour was the main attraction

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