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Cancer breakthrough: New technique spots Cancer Invasion with Fluorescence

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cancer-breakthrough

Scientists at University of California, San Diego School of Medicine have developed a new technique that will allow surgeons to identify during surgery which lymph nodes are cancerous so that healthy tissue can be saved.

One of the greatest challenges faced by cancer surgeons is to know exactly which tissue to remove, or not, while the patient is under anesthesia. A team of surgeons and scientists at University of California, San Diego School of Medicine have developed a new technique that will allow surgeons to identify during surgery which lymph nodes are cancerous so that healthy tissue can be saved. The findings will be published in the January 15 print edition ofCancer Research.

“This research is significant because it shows real-time intraoperative detection of cancer metastases in mice,” said Quyen T. Nguyen, MD, PhD, associate professor of Head and Neck Surgery at UC San Diego School of Medicine. “In the future, surgeons will be better able to detect and stage cancer that has spread to the patient’s lymph nodes using molecules that were designed and developed at UC San Diego.”

Lymph nodes, located throughout the body, serve as filters that contain immune cells to fight infection and clean the blood. When cancer cells break away from a tumor, the cells can travel through the lymph system and hide in these tiny organs. Surgeons remove the nodes to determine if a cancer has spread. However, human nodes, only half a centimeter in size, are difficult to discern among the surrounding tissue during surgery. Furthermore, even when surgeons are able to map the location of the nodes, there is no current technique that indicates whether or not the lymph nodes contain cancer, requiring removal of more lymph nodes than necessary.

“With molecular-targeted imaging, surgeons can avoid unnecessary removal of healthy lymph nodes which is better long-term for patients,” said Nguyen, director of the facial nerve clinic at UC San Diego Health System. “The range of the surgeon’s visual field is greatly enhanced by a molecular tool that can help achieve accurate surgical margins and detection of metastases so that no tumor is left behind.”

The fluorescently labeled molecules, known as ratiometric activatable cell-penetrating peptides (RACPP), are injectable. When used in mouse models, surgeons could see where the cancer had spread with high sensitivity and specificity even when the metastatic sites were only a few millimeters in size.

This form of instant pathology is an improvement over traditional sentinel node mapping, whereby only the location of the lymph node is detected without gleaning any information on actual cancer involvement.

Current methods for managing prostate cancer and neck squamous cell carcinoma only reveal the extent of cancer involvement after the patient has undergone surgical removal of all susceptible lymph nodes.This new technique will decrease OR time because the surgical team need not wait for pathology reports, decrease time under anesthesia, and decrease unnecessary surgery on noncancerous lymph nodes.Nyguyen’s earlier research with Nobel Prize winner Roger Tsien, PhD, professor of pharmacology at UC San Diego School of Medicine, showed in animal models how injectable fluorescent peptides could be used to highlight hard-to-see peripheral nerves, allowing surgeons to avoid them when removing or repairing other tissues.

Contributors to this research paper include Elamprakash N. Savariar, Csilla Felsen, Nadia Nashi, Tao Jiang, Lesley G. Ellies, Paul Steinbach, and Roger Tsien from UC San Diego.
Source: University of California, San Diego School of Medicine

Misc News/Press Release

Himachal: 10 COVID-19 Deaths in Single Day Take Tally to 145, DDU MS Replaced Following Patient Suicide

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Shimla-DDU covid-19 patient suicide 2

Shimla-Himachal Pradesh reported 10 COVID-19 deaths on September 24, 2020, which took the state’s death tally to 145. This is the biggest single-day-spike in the fatalities – a matter of huge worry amid community spread. Kangra district reported the highest six deaths while Shimla, Chamba,  Sirmaur, and Kullu reported one death each. The deceased including eight males and two females were aged between 55-78 years. At least five of these deceased were patients of diabetes mellitus.So far,

So far,  Kangra district has reported the highest 37 deaths, followed by Shimla (24), Solan (23), Mandi (20), Una (10), Sirmaur (10), Chamba (8), Hamirpur (6), Kullu (5), Bilaspur (1), and Kinnaur (1).

Go through the reasons of deaths given by the state Health Department below:Himachal pradesh corona deaths Sept 24

According to the official update, 337 new positive cases were registered yesterday. The total for the state has now reached 13,386. (Scroll down to view statistics for all districts)

DDU MS Replaced After COVID-19 Patient Suicide 

As part of the damage control, the Medical Superintendent of Shimla’s Deen Dayal Upadhyay (DDU) Hospital, Lokender Sharma, was replaced after a COVID-19 patient committed suicide inside the hospital premises. Dr Ramesh Chauhan has been appointed as the new MS.  The case has led to protests against poor facilities and mismanagement in COVID-19 hospitals in the state. The opposition even staged a protest on September 5.

Reacting to his removal, Dr Lokender denied any negligence on his part and said he had been working with insufficient staff and limited facilities. He also alleged that the administration did not consider his repeated complaint regarding the same. Himachal Pradesh Medical Officers Association (HMOA) has also pointed out that the state government has not done anything to chalk out a comprehensive strategy to deal with the pandemic. They also pointed out the lack of trained staff.

These developments, including a sudden spurt in the fatality rate among COVID-19 patients, are now exposing the poor preparedness of the state government. The government doesn’t seem to have any clue about controlling the spread. There is no data on the projected number of actual cases as it is not possible to trace all infected amid a community spread.

While there is a dire need to make more efforts to save lives, the government and the Chief Minister Jairam Thakur appear to be busy in preparing for the visit of the Prime Minister Narender Modi for the opening of the Rohtang Tunnel.

HP Health Department COVID-19 Bulletin- September 24, 2020 (9 PM)

DDU COVID Patient suicide in himachal pradesh

Feature Photo: [email protected]

 

 

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Five More COVID-19 Deaths, Three Suicides, Shimla’s Kotkhai Nagar Panchayat Sealed

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shimla kotkhai nagar panchayat sealed

Shimla– Five more COVID-19 casualties were reported in Himachal Pradesh on September 23, 2020. According to the official update from the Health Department, a total of 280 cases were reported till 9:00 pm today . The COVID-19 death tally is rising at an alarming rate with the onset of a community spread. Currently, a total of 135 persons have lost their lives due to COVID-19.(Scroll down for district-wise statistics)

These deaths were reported from Solan (1), Kangra (2), and Mandi (2). The deceased aged between 58 years to 77. Read the reasons for deaths below:

Shimla- kotkhai nagar panchayat sealed

Kotkhai Nagar Panchayat Sealed for Four Days

Kotkhai Nagar panchayat of Shimal district was sealed today after four persons tested positive at the CHC, Kotkhai. However, there is one case which has increased worries for both the people and the administration.

According to the BMO, Kotkhai, one of these persons, identified as Kavinder Kanwar, runs a car parking at the Kotkhai Bazaar. He also runs a newspaper distribution agency in the same area and deals in mobile recharge business. He frequently handles keys of cars parked in the parking as part of his routine task, it was informed.

“It is quite possible that the concerned positive person has also surely visited several shops and public places in Kotkhai bazaar during the last four days. In this situation, it is difficult to find out the exact contact tracing history due to which there is a high risk of surface transmission and risk of a direct contact person to person,”

informed the Sub-Divisional Magistrate, Theog, in a notification issued today.   

Therefore, the administration has declared the entire Kotkhai Nagar panchayat as containment zone and sealed it except for essential services for four days (till September 27th).

The local police have been directed to restrict any entry to or exit from the area. The BMO has been asked to undertake contact tracing and the Secretary of the Nagar panchayat area has been directed to sanitize the entire area.   

COVID-19 Positive Woman Ends Life at DDU, Shimla

A woman, who was tested positive for COVID-19, and was admitted to the DDU hospital, Shimla, ended her life on the intervening night of September 22-23. The exact reason for the suicide was yet to be ascertained.

Further, two suicides in Kangra district have been associated with the financial distress caused by the COVID-19 pandemic. One of the deceased worked at a fuel station.  The second person was a cab driver. According to the English daily, The Tribune, he had recently received a notice from the bank over non-payment of his loan that he had taken to buy a cab. These suicides are indicators that the people are in dire need of relief from the state government. 

HP Health Department COVID-19 Bulletin- September 23, 2020 (9 PM)

Himachal Pradesh COVID-19 Fatalities on september 23

 

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13 More COVID-19 Deaths in 2 Days, Total Mounts to 130

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Himachal Pradesh COVID-19 update for september 22, 2020

The COVID-19 fatality rate in Himachal Pradesh is on the rise as the death tally reaches 130 with 13 new deaths in the last two days. According to the Health Department’s official COVID-19 Bulletins, State reported seven deaths on September 21 and six on September 22. 

Today, the state registered 331 new confirmed cases with which the COVID-19 tally for the state rose to 12769. Of this total, 4124 are active cases, 8491 have recovered, and 20 migrated to outside the state. The infected also include Nachan MLA Vinod Kumar.

Details of COVID-19 Casualties on Sept 21-22

details of COVID-19 deaths in Himachal pradesh

Today, the highest cases were reported from Sirmaur district (79), followed by Mandi (66), Shimla 48, and Solan 38, and Kullu (25). (Scroll down to view more district-wise statistics.)
However, the actual number of cases could be higher as the state is in the community spread phase. No projection regarding the actual number of cases and deaths has been issued by the state government.

So far, the state government has tested only 271449 persons for COVID-19. Considering the community spread, the state government is supposed to increase the number of tests.

Meanwhile, Chief Minister Jairam Thakur said that people should refrain from going to crowded places and take all precautions. However, tourists thronging the state are hardly following any rules. After lifting all restrictions on inter-state movement, the state government is now preparing to open the inter-state bus services, which would fuel the community spread.  The people are already expressing their resentment with the decision to suddenly lift all restrictions on movement of tourists. Amid these uncertain circumstances, rising fatality rate is the main concern. 

HP Health Department COVID-19 Bulletin- September 12, 2020 (9 PM)

  

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