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Cancer breakthrough: New technique spots Cancer Invasion with Fluorescence

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Scientists at University of California, San Diego School of Medicine have developed a new technique that will allow surgeons to identify during surgery which lymph nodes are cancerous so that healthy tissue can be saved.

One of the greatest challenges faced by cancer surgeons is to know exactly which tissue to remove, or not, while the patient is under anesthesia. A team of surgeons and scientists at University of California, San Diego School of Medicine have developed a new technique that will allow surgeons to identify during surgery which lymph nodes are cancerous so that healthy tissue can be saved. The findings will be published in the January 15 print edition ofCancer Research.

“This research is significant because it shows real-time intraoperative detection of cancer metastases in mice,” said Quyen T. Nguyen, MD, PhD, associate professor of Head and Neck Surgery at UC San Diego School of Medicine. “In the future, surgeons will be better able to detect and stage cancer that has spread to the patient’s lymph nodes using molecules that were designed and developed at UC San Diego.”

Lymph nodes, located throughout the body, serve as filters that contain immune cells to fight infection and clean the blood. When cancer cells break away from a tumor, the cells can travel through the lymph system and hide in these tiny organs. Surgeons remove the nodes to determine if a cancer has spread. However, human nodes, only half a centimeter in size, are difficult to discern among the surrounding tissue during surgery. Furthermore, even when surgeons are able to map the location of the nodes, there is no current technique that indicates whether or not the lymph nodes contain cancer, requiring removal of more lymph nodes than necessary.

“With molecular-targeted imaging, surgeons can avoid unnecessary removal of healthy lymph nodes which is better long-term for patients,” said Nguyen, director of the facial nerve clinic at UC San Diego Health System. “The range of the surgeon’s visual field is greatly enhanced by a molecular tool that can help achieve accurate surgical margins and detection of metastases so that no tumor is left behind.”

The fluorescently labeled molecules, known as ratiometric activatable cell-penetrating peptides (RACPP), are injectable. When used in mouse models, surgeons could see where the cancer had spread with high sensitivity and specificity even when the metastatic sites were only a few millimeters in size.

This form of instant pathology is an improvement over traditional sentinel node mapping, whereby only the location of the lymph node is detected without gleaning any information on actual cancer involvement.

Current methods for managing prostate cancer and neck squamous cell carcinoma only reveal the extent of cancer involvement after the patient has undergone surgical removal of all susceptible lymph nodes.This new technique will decrease OR time because the surgical team need not wait for pathology reports, decrease time under anesthesia, and decrease unnecessary surgery on noncancerous lymph nodes.Nyguyen’s earlier research with Nobel Prize winner Roger Tsien, PhD, professor of pharmacology at UC San Diego School of Medicine, showed in animal models how injectable fluorescent peptides could be used to highlight hard-to-see peripheral nerves, allowing surgeons to avoid them when removing or repairing other tissues.

Contributors to this research paper include Elamprakash N. Savariar, Csilla Felsen, Nadia Nashi, Tao Jiang, Lesley G. Ellies, Paul Steinbach, and Roger Tsien from UC San Diego.
Source: University of California, San Diego School of Medicine

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Himachal Records Fresh Spell of Snow, HP Met Issues Alert

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Shimla-The weather in Himachal Pradesh has taken a turn with a prediction of rain and snowfall till December 5, 2021. At the time of writing this report, Kaza in Lahaul-Spiti was receiving a fresh spell of snow, cheering the tourists, as well as, the hoteliers. So far, the traffic movement was normal in the region.

This has caused a sharp drop in temperatures across the state.

The District Administration of Lahaul-Spiti has advised the locals and tourists to avoid wandering to high altitude areas unnecessarily.

The HP Meteorological Department, Shimla, has also issued a yellow alert for December 2 and December 5. While the plains can experience light to moderate rainfall at a few places,  the middle and higher hills could witness widespread rain and snow on December 2.   

For December 4, the HP Met had predicted light to moderate rain across the state. For December 5, however, the Met has issued an yellow alert with a prediction of rain and snow at several places.

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UHF Nauni Extends Online Plant Booking Date Till Dec 7

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Solan-Dr. YS Parmar University of Horticulture and Forestry (UHF), Nauni has extended the last date for online booking of planting material prepared by the university’s main campus and its Krishi Vigyan Kendra(KVK) at Solan. Interested farmers will now be able to book plants on the university online portal till December 7.

This year the booking for the planting material of apple, plum, apricot, peach, kiwi, pear, pomegranate, persimmon, etc. is being done online and farmers can submit their demand for plants by logging on the university website and visiting the ‘Farmers corner’ section. The university has advised the farmers to register themselves through their email address on the university portal.

The farmers who have not been able to submit their demand forms have also been advised to resubmit their demand forms.  

Applicants will have to fill in their complete postal address and the Khasra number of the land where the planting is to be carried out along with their contact details. After the OTP-based registration process is complete, applicants will be able to book plants for varieties supplied by the university. The plant varieties available for sale and distribution on this web portal have been grafted on seedling rootstock. The procedure for the sale and distribution of Nursery Fruit Plants from other University Research Stations and KVK’s will be the same as in previous years.

The university will start the allotment process after the booking is closed. Based on the total demand, the university will allot plants out of the available quantity. The allotment list will be made available on the university portal. The farmers will be also be notified about the date on which the plant will be available and from which nursery they will be provided.

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HP Police Becomes 8th State Police of India to Receive Presidents Colour Award

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Shimla-Himachal Pradesh Police organized the Presidents Colour Award ceremony at the historic Ridge Ground on December 1, 2021.

Governor Rajendra Vishwanath Arlekar was the Chief Guest and Chief Minister Jai Ram Thakur was also present as a special guest on the occasion. The Governor honoured the State Police with the Presidents Colour Award which was received by the Director-General of Police Sanjay Kundu.

While extending greetings and expressing happiness on receiving the Presidents Colour by Himachal Pradesh Police, the Governor said that it was the 8th State Police of India which has received this distinction.

“President Colour’ is a special achievement and this proves the state police ranks high in the service of humanity along with performance, professionalism, integrity, protection of human rights and other parameters,” said the Governor.

HP Police Presidents Colours award ceremony

The Governor honoured the State Police with the Presidents Colour Award which was received by the Director-General of Police Sanjay Kundu.

He added that this feat has also been given to the State Police for the contribution of its personnel, who have worked tirelessly over the years to make it reliable, professional, honest and people-friendly. He said it would definitely motivate the Police personnel and they would work more readily in public service.

While interacting with media on the occasion, Chief Minister Jai Ram Thakur congratulated the State Police for being awarded President’s Colours by the President of India for its meritorious services. He said that this Award was the highest point in the professional life of any uniform. 

Director-General of Police Sanjay Kundu said that the President’s Color’was not only an award but also a responsibility, which the Himachal Pradesh Police has to fulfil with more integrity, efficiency and discipline.

He added that every Jawan of the State Police should take a pledge to maintain security and peace in Devbhumi Himachal Pradesh.

Earlier, the Governor inspected the Parade. On the occasion, the formation of Hollow Square by the Police Band, Pilling of drums and consecration of the colour was the main attraction

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